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CARDIAC MYOCYTE POTENTIALS #Pathophysiology #Cardiology #Cardiac #Myocyte #Ventricular #ActionPotentials #Channels #Phases
#Ventricular #ActionPotentials ... #Channels #Phases
Drugs affecting the cardiac action potential. The sharp rise in voltage ("0") corresponds to the influx
to the sodium-channel ... voltage-sensitive calcium channels ... Classes #Effect #ActionPotentials
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Depolarization: • Na+ channels ... Phase • Ca++ channels ... Potential: • K+ channels ... CLASS 1 - Sodium Channel ... Block fast Na+ channels
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
CLASS 1 - Sodium Channel ... Block fast Na+ channels ... 3 - Potassium Channel ... MOA: Block K+ channels ... Block slow Ca++ channels
Antiarrhythmic Medications - Vaughan Williams Classification - Summary Table Class I agents - Sodium Channel Blockers⠀ Class II
agents - Sodium Channel ... agents - Potassium Channel ... agents - Calcium Channels
Antiarrhythmics - Sodium Channel Blockers Subclasses, Mechanisms, Indications, Side Effects la - Quinidine, Procainamide lb - Lidocaine, Mexiletine Ic -
Antiarrhythmics - Sodium Channel ... Antiarrhythmics #Sodium #Channel ... pharmacology #table #comparison
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
cotransporter, K channel ... , Cl channel, or ... barrtin (recruits Cl channel ... epithelial sodium channels ... epithelial sodium channels
Diuretic Electrolyte Excretion Effects Diuresis, Na+, K+, Mg2+, Ca2+, Cl-, HCO3-, Uric Acid - Thiazide Type
Epithelial Sodium Channel ... #pharmacology #comparison
Toxidromes Summary Table Heart Rate - Respiratory Rate - Blood Pressure - Mental Status - Skin -
Cholinergic • Ion Channel ... (BB) • Ion Channel ... #Toxidromes #comparison
Action potential in cardiomyocytes The action potential in typical cardiomyocytes is composed of 5 phases (0-4), beginning
Pathophysiology #Cardiac #ActionPotential
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