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Membrane Actions of Antiarrhythmic Drugs

#Membrane #Channels #Actions #Antiarrhythmic #Drugs #Medications #Pharmacology #Cardiology #Table
Membrane Actions ... Membrane #Channels #Actions ... #Pharmacology #Cardiology
Class I Antiarrhythmics and their Key Pharmacologic Properties

Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer")
Class IB
fast-response cardiac action ... This type of action ... ) due to their actions ... repolarization of action ... Pharmacology #Agents #Cardiology
Cardiac Myocyte Contractile cycle
 - Ca2+ binds to TnC → TnI is inhibited → conformational change
active site between actin ... active sites on actin ... ” myosin along actin ... releasing the actin ... Pathophysiology #Cardiology
Pharmacology of diuretics

Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride

Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
Amiloride Site of Action ... Thiazide #CHF #Cardiology
Drugs affecting the cardiac action potential. The sharp rise in voltage ("0") corresponds to the influx
affecting the cardiac action ... #Pharmacology #Cardiology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
, Intermediate Action ... Blockade, Fast Action ... Blockade, Slow Action ... inotropy) ACCP Cardiology ... pathophysiology #cardiology
Antiarrhythmics - Vaughan Williams Classification
Class I (Ia, Ib, Ic) - Na+ Channel Blockade
 • Slows depolarization
Blockade • Prolongs action ... Classification #Classes #cardiology
Medications Used in Congestive Heart Failure

In CHF, the heart is failing as a pump; cardiac output
#Medications #Action ... #HeartFailure #Cardiology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
, Intermediate Action ... Blockade, Fast Action ... Blockade, Slow Action ... inotropy) ACCP Cardiology ... pathophysiology #phases #cardiology
Acute Atrial Fibrillation - Initial Options for Rate Control
Diltiazem IV
 •  Rapid onset and rapidly
Fibrillation - Initial Options ... as with other options ... Slowest onset of action ... pharmacology #management #cardiology