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diagnosis differential management injury lfts transaminitis aclf acute aih autoimmune causes chemistry cirrhosis dili druginduced failure gastroenterology hbv hepatitisb interpretation
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... - Chronic hepatitis ... AST:ALT > 2.5 - Alcoholic ... #Patterns #Liver ... #Injury #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... #Cirrhosis #Hepatology
Alcoholic Hepatitis - Management Algorithm 1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... - Management Algorithm ... can be bridge to Liver ... #Algorithm #treatment ... #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... and Management Algorithm ... Chronic Hepatitis ... #Management #Treatment ... #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • NAFLD • Alcohol ... disease US — Normal ... hepatitis • Drugs ... Others #LFTs #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... HEV, EBV, CMV), Alcohol-related ... hepatitis fibrosis ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... function may be abnormal ... ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... viral hepatitis ... injury: > 3 • Chronic ... #differential #Hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... - Symptoms of chronic ... upper limit of normal ... regarding need for treatment ... Diagnosis #Management #Hepatology
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