14 results
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... Injury (DILI) ... #Hepatology #gastroenterology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... HEV, EBV, CMV), Alcohol-related ... #Diagnosis #Algorithm ... #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... cirrhosis, Portal ... AST:ALT > 2.5 - Alcoholic ... #Patterns #Liver ... #Injury #hepatology
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Differential Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... Inflammatory • Alcoholic ... Primary Biliary Cirrhosis ... #Causes #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... disease US — Normal ... hepatitis • Drugs ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... • Iatrogenic: DILI ... ALT Ratios: • Alcoholic ... : < 1 • Cirrhosis ... #hepatology
Alcoholic Hepatitis - Management Algorithm
1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... - Management Algorithm ... can be bridge to Liver ... #Algorithm #treatment ... #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... - NAFLD, Alcohol ... Congenital, Others, Cirrhosis ... #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... ALT Ratios: • Alcoholic ... : < 1 • Cirrhosis ... #differential #Hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
and Management Algorithm ... viremia or have cirrhosis ... #HBV #Algorithm ... Diagnosis #Management #Treatment ... #Hepatology