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diagnosis differential causes injury lfts transaminitis biliary chemistry cirrhosis druginduced hellp icp interpretation liverenzymes obstetrics pbc pregnancy primary rvalue transaminases
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
• Autoimmune: ... Autoimmune hepatitis ... • Iatrogenic: DILI ... specificity to elevated ... #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... Metabolic: Wilson Disease ... obstruction syndrome • Autoimmune ... : DILI, Tylenol, ... Diagnosis #causes #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ... steatosis • Autoimmune ... hepatitis #DILI ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Ischemia • Autoimmune ... • Pregnancy - AFLP ... • Cholestatic disease ... • Alcoholic hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Check Acute viral hepatitis ... specificity to elevated ... of cholestatic disease ... disease: > 2 ... #differential #Hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... Mild jaundice, Elevated ... of Pregnancy (AFLP ... #hepatology #obstetrics ... #hepatitis #comparison
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
disease (e.g. dryness ... disease, Persistent ... Elevated ALP 2. ... Liver biopsy findings ... #hepatology
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