6 results
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... Contraindications: • Chronic kidney ... #Pharmacology # ... Summary #DM2 #diabetes ... #endocrinology
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
initiation of treatment ... ml/min per 1.73 m2 ... ADA/KDIGO Consensus ... evidence-based pharmacologic ... Diabetes #CKD #ADA
Management of Polycystic Ovary Syndrome (PCOS)
Hyperandrogenism, Family Planning, Endometrial cancer prevention, Cardiovascular risk factor management
→ Weight
Reduction (5-10%) (No FDA ... approved treatments ... Metformin 3. ... Letrozole (BMI >30 kg/m2 ... Syndrome #Management #endocrinology
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
in the nephron (kidney ... combo product with metformin ... SGLT2 #Inhibitors #Pharmacology ... #Medications #DM2 ... #Diabetes #Endocrinology
Estimating the Total Daily Dose (TDD) of Insulin: Weight-Based Dosing
TDD in units of insulin = N
elderly, chronic kidney ... Add sliding scale ... Weight #Based #pharmacology ... #endocrinology ... #diabetes #DM2
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
patients have renal ... double check the kidney ... #Dosing #Pharmacology ... Management #Diabetes #DM2 ... #Endocrinology