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management oncology rheumatology differential leukemia algorithm chronic cll erythematosus lupus lymphocytic sle systemic treatment abnormal activation agglutinin alkaline alp aplastic
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Clinical Presentation ... • Improve the symptoms ... #oncology #hematology ... #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... of anemia include ... anemia • Cold ... #hematology #diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... immunophenotype Clinical ... marrow failure with anemia ... Leukemia #oncology #hematology ... #hemeonc #diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... Fever is the main clinical ... with leukopenia, anemia ... #Diagnosis #Management ... #Hematology #Rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Demyelinating syndromes ... ) Blood (75%): Anemia ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... blood cell count (anemia ... • Aplastic Anemia ... Megaloblastic Anemia ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... with no early symptoms ... • Neutropenia, anemia ... • Richter’s Syndrome ... workup #oncology #hematology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
hyperbilirubinemia syndrome ... as jaundice on clinical ... examination; nonspecific symptoms ... Congenital #bilirubin #hepatology ... #diagnosis #gastroenterology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... HLH signs and symptoms ... Diagnosis via genetic ... management #treatment #hematology
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