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hematology management apml cell differential differentiation disease gap globulin igg4 phenotypes plasmacytoma protein proteingap related solitary syndrome thromboticthrombocytopenicpurpura ttp
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
pancreas, biliary, renal ... orientation, Biopsy ... orientation): ... management #phenotypes #workup ... #treatment #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Anaphylaxis, Acute Renal ... Failure Treatment ... #management #hematology ... #oncology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... activity is the diagnostic ... available for rapid diagnosis ... the presence of renal ... #Workup #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... first step in evaluation ... cancers, HCC, renal ... #differential #diagnosis ... #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Evaluation? ... Bone marrow Treatment ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology
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