16 results
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... 40, F:M 9:1 • Clinical ... Photosensitivity, Alopecia ... Usual therapeutic management ... Erythematosus #Diagnosis #Management
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... 40, F:M 9:1 • Clinical ... Photosensitivity, Alopecia ... Usual therapeutic management ... rheumatology #diagnosis #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... develops on the background ... Fever is the main clinical ... erythematosus [SLE ... Syndrome #Diagnosis #Management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... and permanent alopecia ... lymphoproliferative syndrome Clinical ... • Nonscarring alopecia ... Chronic B-cell activation
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19

IL-6 activates T cells and macrophages, among other cell types (see
other cell types (see ... “Cytokine Activation ... Siltuximab #COVID19 #Pharmacology ... #Management #Medications
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... Autoimmune diseases: SLE ... Lymphohistiocytosis #diagnosis #management
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Diagnosis and Management ... complex → plt activation ... Diagnosis: • Clinical ... Confirmatory test ↑Se ... non-heparin A/C if clinical
IDSA Recommendations for Preventing and Treating Chagas Disease (American Trypanosomiasis) in HIV-AIDS
Preventing Clinical Disease
Indication:  Individuals
HIV-AIDS Preventing Clinical ... ART may prevent reactivation ... and preventing clinical ... Prevention #Treatment #management ... infections #HIVAIDS #pharmacology
Pain, Agitation, and Delirium (PAD) in the ICU
Addressing the ICU Triad (PAD) can be accomplished through
Family engagement Critical ... will vary with clinical ... No pharmacologic ... (Haldol) - No pharmacologic ... CriticalCare #diagnosis #management
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Excessive activation ... Transverse Myelitis - Clinical ... Evaluate for NMO, SLE ... Disorders: - SLE ... Myelitis #diagnosis #management