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diagnosis hemolytic workup causes agglutinin algorithm bloodcell cancer chronic classification cll disease emergencies extravascular hemolysis hodgkins intravascular leukemia lymphocytic lymphoma
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Unstable hemoglobin disorders ... , Paroxysmal cold ... #Morphology #differential ... #diagnosis #hematology ... #microscopy #atlas
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... Blood smear - RBC ... younger pts) Differential ... #hematology #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... practices that could ... (CVID, WAS), (neurologic ... changes), high MCV anemia ... #Differential #
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold ... membrane disorder ... Algorithm #workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
lymphoproliferative disorders ... • Intrinsic RBC ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
- Differential ... Diagnosis Framework HEMATOLOGIC ... of breath • Neurologic ... Leukostasis: • WBC ... Epidural Spinal Cord
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
et diutinum Neurologic ... +Organomegaly+↑RBC ... (-) hemolytic anemia ... due to cold IgG ... #Diagnosis #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... lymphoproliferative disorders ... • Neutropenia, anemia ... diagnosis #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
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