Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes), Sideroblastic anemia (sometimes) Macrocytic RBC: Vitamin B12 or Folate deficiency, Liver Disease, MDS, Chemotherapy (e.g. methotrexate) Spurr Cell RBC (Acanthocyte): Abetalipoproteinemia, Liver disease, McLeod blood group phenotype, Post-splenectomy, Etc. Burr Cell RBC (Echinocyte): Artifact, Uremia, Liver disease, Etc. Schistocyte: Microangiopathic Hemolytic Anemia, Mechanical valve induced, Etc. Bite Cell RBC: G6PD deficiency, Unstable hemoglobin disorders, Oxidative drugs Elliptocyte: Hereditary elliptocytosis, Severe iron deficiency anemia Spherocyte: Hereditary spherocytosis, Autoimmune hemolytic anemia Stomatocyte: Hereditary stomatocytosis, Liver disease Target Cell RBC: Thalassemia, Hemoglobinopathies, Post-splenectomy, Liver disease, Artifact Sickle Cell RBC: Hemoglobin SS disease, Hemoglobin SC disease, Hemoglobin SD disease, S-beta thalassemia Teardrop: Myelofibrosis, Underlying marrow process/infiltrate, Etc. Hemoglobin C Crystals: Hemoglobin C disease, Hemoglobin SC disease Red Cell Agglutinate: Cold autoimmune hemolytic anemia, Paroxysmal cold hemoglobinuria, IgM associated lymphoma, Multiple myeloma Rouleaux: Chronic liver disease, Malignant lymphoma, Multiple myeloma, Chronic Inflammatory Diseases #Red #BloodCell #RBC #Morphology #differential #diagnosis #hematology #microscopy #atlas #nomenclature
