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Dacrocytes (tear drop cells) 
Other poikilocytes resemble a pear or teardrop. The narrow, tapered end
may be
each of the above photos ... metaplasia, pernicious anemia ... some hemolytic anemias ... #Clinical #Path ... BloodSmear #Blood #Smear
Codocytes (Target cells) - Two target cells are seen in the left photo and one in
seen in the left photo ... present in the left photo ... with hemolytic anemias ... #Clinical #Path ... BloodSmear #Blood #Smear
Elliptocyte - 
Note the shape of these appropriately named erythrocytes.
In addition to hereditary elliptocytosis, elliptocytes can
megaloblastic anemia ... myelophthisic anemia ... sideroblastic anemia ... #Clinical #Path ... BloodSmear #Blood #Smear
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... Abnormal peripheral smear ... #Hemolytic #Anemias ... Diagnosis #Algorithm #hematology
Here is another peripheral blood smear demonstrating changes with iron deficiency anemia. Note the increased zone
peripheral blood smear ... iron deficiency anemia ... #Clinical #Path ... PeripheralBloodSmear #BloodSmear #Anemia
The arrows point to blister cells. These cells are thought to be precursors of helmet cells.
The photo on the ... #Clinical #Path ... BloodSmear #Blood #Smear
Spherocytes - The arrow points to one of many spherocytes in this photo. The cells have
spherocytes in this photo ... This smear was from ...

Causes of spherocyte ... and hemolytic anemias ... #Clinical #Path

Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood Smear ... Megaloblastic Anemia ... Autoimmune hemolytic anemia ... Peripheral #Blood #Smear ... #Analysis #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Normochromic RBCs on Smear ... Spherocytes on Smear ... Diagnosis #Algorithm #Causes ... #Hematology
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Testing in Hemolytic Anemia ... LDH Peripheral smear ... #Hemolytic #Anemia ... workup #diagnosis #hematology