1191 results
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
/SSA & Anti-La/SSB ... gland) biopsy • Ocular ... salivary ducts Clinical ... Disease: • 10%-15% Pulmonary ... , INC risk PE, Pulmonary
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Autoantibodies Anti-topoisomerase ... I (anti-Sc170): ... skin disease, Pulmonary ... fibrosis Anti-centromere ... disease (~93-95%), Pulmonary
Macular Hole  - Slit Lamp Ocular Examination

Dr. Sebastian Vega @oftalmopo

#Macular #Hole #Retina #Ocular #PhysicalExam #clinical
Macular Hole - ... Slit Lamp Ocular ... @oftalmopo #Macular ... #Hole #Retina #Ocular ... #PhysicalExam #clinical
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Presentation (Pulmonary ... Diagnosis for Pulmonary ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... With associated pulmonary ... involvement: Anti-GBM
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... polyangiitis) Anti-basement ... Although pulmonary ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
Biologic therapy for eosinophilic asthma 
• Mepolizumab (Nucala) 
  • Anti-lL-5, 100 mg SQ q4
(Nucala) • Anti-lL ... Cinqair) • Anti-lL ... Fasenra) • Anti-lL ... Dupixent) • Anti-lL ... #pharmacology #pulmonary
Radiographic Features of Pulmonary Diseases
 - Pneumonia
 - Atelectasis
 - Emphysema
 - Pneumothorax
 - Effusion
 -
Radiographic Features of Pulmonary ... Interstitial - Nodular ... Emphysema - Pulmonary ... Embolism - Acute Pulmonary ... Cardiac Failure #Pulmonary
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... Vasculitis - Anti-GBM ... Positive (ANCA + anti-GBM ... Kumfer @AnnKumfer #Pulmonary
Cryptogenic Organizing Pneumonia (COP)

Cryptogenic Organizing Pneumonia Overview:
 • Idiopathic form of organizing pneumonia
 • formerly BOOP
Organizing Pneumonia - Clinical ... RF, CCP, CPK, anti-scl70 ... anticentromere ab, Anti-dsDNA ... eosinophilia pneumonia, Pulmonary ... Pneumonia #COP #BOOP #pulmonary