Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: - ANCA Associated Vasculitis - Anti-GBM Disease - Double Positive (ANCA + anti-GBM) 10%: - Low Complement Levels: SLE, Cryoglobulinemic, MCTD, Antiphospholipid Syndrome, Rheumatoid Vasculitis - Normal Complement Levels: Scleroderma Renal Crisis, IgA Vasculitis, Behcet's Disease, Inflammatory Myositis MIMICS: - Infections: Hantavirus infection/other hemorrhagic fevers, Leptospirosis, Legionellosis, Malaria, Babesiosis, Disseminated S. aureus infection, ARDS with multiorgan failure - Cancer: Amyloidosis, differentiation syndrome in APL - Cardiac: heart failure, cardiac tumor, mitral valve disease, Malignant hypertension - MAHA: HUS, atypical HUS, TTP, DIC Dr. Ann Marie Kumfer @AnnKumfer #Pulmonary #Renal #Syndromes #Mimics #Differential #Diagnosis
