2547 results
Hashitoxicosis - Autoimmune thyroid disease overlap syndrome of Graves' and Hashimoto's disease

Autoimmune thyroid disease overlap syndrome
Autoimmune thyroid disease ... and Hashimoto's disease ... TPO) antibodies (Anti-TPO ... Antithyroglobulin (anti-Tg ... Endocrinology #Pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... pulmonary involvement: Anti-GBM ... Disease (Goodpasture's
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... • Autoimmune diseases ... Adult-onset Still disease ... chemotherapy, anti-CD20 ... manifestations, Anti-IFN-y
Hemolytic Disease of the Newborn
All Rh(D)- pregnant women should be screened for anti-Rh(D) antibodies at the
Hemolytic Disease ... be screened for anti-Rh ... should receive anti-Rh ... Prevents hemolytic disease ... #Newborn #pathophysiology
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
Person Syndrome Pathophysiology ... Syndrome: • Anti-GAD ... poisoning, Parkinson's disease ... Baclofen • Severe Disease ... IVIG: Rituximab (anti-CD20
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
• Inflammatory Disease ... and/or decreased anti-coagulation ... • Hematologic Disease ... Occlusion #CRAO #pathophysiology
Keratoconus: Pathogenesis and Clinical Findings
Genetics
 • Family history of keratoconus
 • Ehlers-Danlos syndrome
 • Down, Turner,
VCAM-I) • Decr Anti-inflammatorymarkers ... rubbing • Atopic diseases ... #Keratoconus #pathophysiology
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
Pathogenesis and Joint diseases ... antibodies -> Anti-Cyclic ... RheumatoidArthritis #RA #pathophysiology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... - Graves' disease ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... super-antigen mediated disease ... levels • NMO-IgG (anti-AQP4 ... MCTD - Bechet disease ... AntiCRMP IgG, Anti-Hu