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Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
hypersensitivity reactions ... Form: Soluble antigen ... Allergen-specific lgE causes ... Acute transfusion reaction ... hypersensitivity #reactions
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Penicillin-induced drug reaction ... Immunological Target: Antigen-Ab ... Dermatitis (ie. reaction ... Allergy #Allergic #Reactions
Eosinophils (Eos) and hypereosinophilia (HE) Caused by eosinophilopoietic cytokines Common causes: - Drug reaction - Helminth infection -
hypereosinophilia (HE) Caused ... cytokines Common causes ... : - Drug reaction ... infection - Allergic reaction ... disease Rare causes
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
exposure to allergen causes ... Allergic reaction ... Macrophage engulfs antigen ... -> Antigen presentation ... cells recognize antigen
Allergic Rhinitis: Pathogenesis and clinical findings 1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Sensitization -> Antigen ... class II) process antigen ... Primary Reaction ... Secondary Reaction ... after the primary reaction
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
during an allergic reaction ... Or Inflammatory Reactions ... Chickenpox Other Causes ... Differential #Diagnosis #causes
Hemolysis Classification - Intrinsic and Extrinsic Causes Commentary: Another way to think of immune hemolysis would be
and Extrinsic Causes ... autoimmune (most of the causes ... hemolytic transfusion reactions ... Differential #Diagnosis #Causes
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
blisters, possibly crusts ... Bullous impetigo - Reaction ... diabeticorum) - Reaction ... Diagnosis #Algorithm #causes
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
cell surfaces causes ... against the antigen ... cell surface, and antigen-surface ... small antibody-antigen ... exposure to allergen causes
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
lgE - Soluble antigen ... IgM - Cell-bound antigen ... IgM - Soluble antigen ... - Antigen-antibody ... Allergy #Diagnosis #Reactions
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