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Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
hypersensitivity reactions ... Mediators: lgE - Antigen ... Form: Soluble antigen ... Acute transfusion reaction ... hypersensitivity #reactions
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
Definition: When antigens ... antibody-mediated immune reaction ... These antigens can ... either be self-antigens ... , or foreign antigens
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
to an allergic reaction ... • Type II - Antigenic ... against the antigen ... cell surface, and antigen-surface ... small antibody-antigen
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Penicillin-induced drug reaction ... Immunological Target: Antigen-Ab ... Dermatitis (ie. reaction ... Allergy #Allergic #Reactions
Allergic Rhinitis: Pathogenesis and clinical findings 1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Sensitization -> Antigen ... class II) process antigen ... Primary Reaction ... Secondary Reaction ... after the primary reaction
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
lgE - Soluble antigen ... IgM - Cell-bound antigen ... IgM - Soluble antigen ... - Antigen-antibody ... Allergy #Diagnosis #Reactions
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
Allergic reaction ... Macrophage engulfs antigen ... -> Antigen presentation ... cells recognize antigen
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
constipation • Allergic reaction ... mediated cytotoxic reaction ... to drug antigens
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion Reactions ... common immune reaction ... once had another reaction ... mismatch of donor antigens ... mismatch of minor antigens
Acute Schistosomiasis: Katayama Fever • Most common in travelers and children • "Swimmers Itch" in the
hypersensitivity reaction ... the schistosome antigens
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