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diagnosis hematology hemolytic cardiology endocarditis agglutinin aiha bloodcell causes cold disease extravascular hemolysis infectiousdiseases intravascular management microscopy morphology nomenclature pancytopenia
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Differential Diagnosis ... Donath-Landsteiner HA (paroxysmal ... #Hemolytic #Anemia
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
spherocytosis, Autoimmune ... Agglutinate: Cold autoimmune ... , Paroxysmal cold ... RBC #Morphology #differential ... hematology #microscopy #atlas
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... Inflammatory and Autoimmune ... erythematosus • HLH • Paroxysmal ... #Pancytopenia #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... Transfusion reaction, Paroxysmal ... idiopathic) - Autoimmune ... Extravascular #Causes #differential ... diagnosis #hematology #anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... • Symptoms of anemia ... CLL (older) • Autoimmune ... younger pts) Differential ... macroglobulinemia Paroxysmal
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
regurgitation • Autoimmune ... Hypercoagulable (APLAS ... Marantic (NTBE) Differential ... Leukocytosis, anemia
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
- Overview and Differential ... regurgitation • Autoimmune ... Hypercoagulable (APLAS ... Leukocytosis, anemia ... #Endocarditis #Differential
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