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diagnosis hematology coagulation aptt prolonged aflp bleeding bruising dermatology disease disseminated hellp hemostasis hepatitis intravascular management nonpalpable obstetrics palpable pregnancy
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
of Pregnancy (ICP ... DIC • Aminotransferases ... Disease #Pregnancy #hepatology ... obstetrics #hepatitis #comparison ... #differential #
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... intravascularcoagulation (DIC ... amyloidosis #Abnormal ... #differential #
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
history of trauma, sepsis ... • Prolonged PT ... Fibrinogen: ↓ • PT ... • Severe Liver ... Treat primary cause
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... intravascular coagulation (DIC ... #differential #
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Acquired: • Heparin ... PT/NORMAL PTT: ... ABNORMAL PT/
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Thrombocytopenia: ITP ... deficiency • Liver ... Cholesterol emboli • Septic ... #Diagnosis #hematology
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