7 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Disseminated intravascular ... Jcortesizaguirr #Abnormal ... #differential # ... hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Disseminated Intravascular ... history of trauma, sepsis ... • Prolonged PT ... Fibrinogen: ↓ • PT ... Treat primary cause
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... amyloidosis #Abnormal ... #differential # ... hematology #coagulation
Etiologies of Hypoaldosteronism

Hyporeninemic Hypoaldosteronism (Low Renin, Low Aldosterone)
 - Diabetic Nephropathy 
 - NSAIDs
Non-Hyporeninemic Hypoaldosteronism (Normal
Inhibitors - Chronic heparin ... or High Renin, Normal ... Hypoaldosteronism #Differential ... #Aldosterone #Comparison ... #Table #Causes
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Acquired: • Heparin ... PT/NORMAL PTT: ... PT/ABNORMAL PTT
Shock - Differential Diagnosis Framework
MAP = CO x SVR
Hypovolemic (↓ Intravascular volume):
 • Hemorrhage, dehydration due
Shock - Differential ... Hypovolemic (↓ Intravascular ... findings based on cause ... #Diagnosis #table ... #comparison #criticalcare
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
be performed PT ... decrease in most cases ... reflection of intravascular ... WBC count and differential ... Diagnosis #Workup #Hematology