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diagnosis hematology causes classification hemolytic oncology agglutinin algorithm cold conjugated disease erythematosus extravascular hodgkins intravascular jaundice lupus monoclonal paraproteinemias platelets
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) (e.g. lupus, CLL ... , lymphoma, idiopathic ... Extravascular #Causes #differential ... #anemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Metastatic cancer, Lymphoma ... Inflammatory Conditions: Rheumatologic
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
autoimmune disorder or lymphoid ... - Monoclonal - Lymphoid ... anemia • Cold ... younger pts) Differential ... #anemia #hematology
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
production (eg, hemolytic ... anemias, hemolytic ... reactions, hematoma ... , sarcoidosis, lymphomas ... #unconjugated #differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... anemia • Pain ... Workup: • Full ... Immunohistochemical studies (to differentiate ... #oncology #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... Marginal zone lymphoma ... • Coombs (-) hemolytic ... anemia due to cold ... #Monoclonal #Differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... , APLA, PAC • Aseptic ... lymphopenia, low PLT • Anemia ... La, anti-Jo-1, SCL
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