25 results
Evaluation of Patients with Anemia

Microcytic, Normocytic, Macrocytic, Hemolytic (Intravascular and Extravascular)

#Diagnosis #Anemia #Workup #Macrocytic #Microcytic #Normocytic
Evaluation of Patients ... with Anemia Microcytic ... Normocytic, Macrocytic, Hemolytic ... #Workup #Macrocytic ... Microcytic #Normocytic #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... G6PD deficiency) ... Extravascular #Causes #differential
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Consider RBC membrane disorder ... #Anemia #Differential ... Diagnosis #Algorithm #workup
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
Algorithm - Iron deficiency ... and/or folate deficiency ... Probable bone marrow disorder ... hematology #diagnosis #differential ... #workup
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... Unstable hemoglobin disorders ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic ... RBC #Morphology #differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... • Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... #anemia #hematology
Causes of Wide Pulse Pressure - Differential Diagnosis
Physiologic:
 • Advanced age-arteriosclerosis (less compliant arteries)
 • Well
Pulse Pressure - Differential ... - Severe iron deficiency ... anemia (reduced ... viscosity) - anemia ... Vasoplegia • Sepsis
Hypocalcemia Workup - Differential Diagnosis Algorithm
 • Low Magnesium, High Magnesium - Functional Hypoparathyroidism
 • High
Hypocalcemia Workup ... - Differential ... , Infiltrative disorders ... Pancreatitis, Sepsis ... #Differential #
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... anemia, PNH, immune ... - Iron deficiency ... paralyses CNS Disorders ... Dehydrogenase #Elevated #differential
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
Algorithm for the evaluation ... Hemorrhage or hemolysis ... of the initial work-up ... if vitamin B12 deficiency ... occur with B12 deficiency