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diagnosis causes abnormal aptt prolonged activation bleeding bruising dic disseminated hemostasis intravascular macrophage mas rheumatology syndrome treatment
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... Reduced liver synthesis ... intravascular coagulation ... Causes #diagnosis #differential ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... DIC • Severe Liver ... causes #treatment #management ... #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... for a Prolonged PT ... • Reduced liver ... Causes #diagnosis #differential ... #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... intravascular coagulation ... Bruising #Hemostasis #Differential ... #Diagnosis #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
brucellosis) • Sepsis ... thrombocytopenia • Liver ... Hypofibrinogenemia • ↑ PT ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
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