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diagnosis differential symptoms neurology algorithm deficiency geriatrics peds 21hydroxylasedeficiency 21ohd alzheimersdisease bariatric beriberi brudzinskis bypass clinical copper cord crisis deficiencies
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
Risk Factors and Signs ... • Nutritional: ... , Malnutrition Signs ... Optic neuropathy, Ataxia ... Deficiency #diagnosis #signs
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Alzheimer’s Disease ... chromosome 21) Signs ... incontinence, apraxia ... AlzheimersDisease #Dementia #pathophysiology ... #geriatrics #diagnosis
Causes of Gait Disturbance - Differential Diagnosis Algorithm Sporadic • Vascular • Infection • Toxic • Nutrition
Causes of Gait Disturbance ... • Toxic • Nutrition ... Degenerative Sensory Ataxia ... Spinocerebellar Ataxia ... • Friedrich's Ataxia
Micronutrient Deficiencies After Gastric Bypass Fat-Soluble Vitamins: • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
Vitamin D - Bone disease ... • Thiamine - Nausea ... dysfunction, gait ataxia ... sensory neuropathy, ataxia ... Bypass #vitamin #nutrition
Refeeding Syndrome: Pathogenesis and clinical findings Patients at Risk of Refeeding Syndrome: - Little or no nutritional
- Little or no nutritional ... CNS: Tremors, Ataxia ... Syndrome #diagnosis #pathophysiology ... #symptoms #signs
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... Cardiovascular disease ... Overproduction #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
Collapse: • Pathophysiology ... → Syncope • Signs ... electrolyte losses - Ataxia ... muscle function, Ataxia ... differential #diagnosis #causes
Brudzinski’s Sign in Meningitis (first described in 19th century by Dr. Josef Brudzinski) Brudzinski's sign is characterized
Brudzinski’s Sign ... Passive neck flexion causes ... While the pathophysiology ... despite severe disease ... #PhysicalExam #Pediatrics
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 21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
Sickle-cell disease ... Sickle cell disease ... The underlying pathophysiology ... ischaemia. 2) Aplasia ... Crisis #Features #Signs
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