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Algorithm for the Evaluation and Management of Transfusion Reactions

This algorithm was developed by Dr. Eric Madden,
Evaluation and Management ... of Transfusion ... Reactions This ... #Transfusion #Reactions ... #Algorithm #Diagnosis
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Reaction (FNHTR ... Reaction (AHTR) ... Reaction (DHTR) ... - Allergic ... #diagnosis #management
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... lgM antibodies bind ... Examples: Acute transfusion ... #types #allergy ... classification #comparison
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
of lgE Abs that bind ... reaction • Type ... An allergic reaction ... #Allergic #Reactions ... Classification #Diagnosis
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Reactions Immune ... Reaction (FNHTR ... Reaction (AHTR) ... • Allergic reaction ... #diagnosis #management
Transfusion Reactions - Summary Cheatsheet
 • Hemolytic Reaction
 • Febrile Reactions
 • Transfusion Related Acute Lung
Transfusion Reactions ... Cheatsheet • Hemolytic Reaction ... • Febrile Reactions ... #Reactions #diagnosis ... #management #hematology
Angioedema - Classification Diagnosis and Treatment
Types of Angioedema:
 • Acute allergic angioedema - Usually occurs with
Classification Diagnosis ... drug reaction - ... Classification #Types #Diagnosis ... #Treatment #management ... #allergy
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... lgE antibodies bind ... When the specific allergen ... destruction after transfusion ... #Diagnosis #Reactions
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
TRALI vs TACO - Transfusion ... Reactions TRALI ... plasma volume transfusion ... #Reactions #hematology ... #diagnosis #comparison
When assessing a patient with acute dyspnea during or shortly following a transfusion, it is challenging
shortly following a transfusion ... #Diagnosis #Transfusion ... #Reaction #TRALI ... #TACO #Comparison