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management rheumatology differential hemophagocytic lymphohistiocytosis product reactions treatment causes erythematosus hemeonc hodgkins hypokalemia infectiousdiseases lupus lymphoma macrophage mas mycobacteria nontuberculous
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... Phagocytosis of blood ... Auto-amplification loop Diagnosis ... treatment #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... can mimic common infections ... Splenomegaly • Low ... Treatment: • Infection ... management #treatment #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... lymphohistiocytosis (HLH ... inflammatory disease How ... SLE], AOSD) • Infection ... #Syndrome #Diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... Count - Low Hb ... may be high or low ... #classification ... #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
by uncontrolled activation ... Triggers: ▪ Infections ... Low/absent NK-cell ... underlying trigger: Infections ... #Management #Hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
cutaneous eruptions, diarrhea ... potassium from ... Hypothermia: Due to low ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
cutaneous eruptions, diarrhea ... potassium from ... Hypothermia: Due to low ... #Transfusions #diagnosis ... #management #hematology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Slow Growers (Runyon ... Classification ... Growers (Runyon Classification ... Hematologic malignancy ... liver enzymes, diarrhea
Causes of Hypokalemia I. Decreased intake A. Starvation B. Clay ingestion II. Redistribution into
factor (white blood ... Gastrointestinal loss (diarrhea ... #Differential #Diagnosis ... #Low #Potassium ... #Classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... Skin Disease Classification ... fibromyalgia) • Infections ... , lymphopenia, low ... Chronic B-cell activation
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