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diagnosis differential management blood reactions vasculitis activation aids classification clues hemophagocytic hiv hlh immunecompromised immunocompromised infections infectiousdiseases lung lupus lymphohistiocytosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... [SLE], AOSD) • ... Fibrin degradation products ... Diagnosis #Management #Hematology ... #Rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
9) Unexplained fever ... children (pediatric SLE ... lupus #diagnosis #sle ... #erythematosus # ... rheumatology
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
papules, pustules, erythematous ... • Risk: Can produce ... function of alveolar macrophages ... pain, chronic diarrhea ... vomiting, and diarrhea
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
S/sx: Fever, flank ... Causes purpura & ... Sx include: fever ... cutaneous eruptions, diarrhea ... diagnosis #management #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... Better call hematology ... some time, let’s see ... - Some tumors produce ... #workup #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
activation of macrophages ... • Clinical: fever ... Autoimmune diseases: SLE ... Drugs, Unknown cause ... treatment #summary #rheumatology
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Differential Diagnosis Algorithm ... Bronchitis • Chronic Diarrhea ... Infection #Fever ... #Causes #Hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
S/sx: Fever, flank ... Causes purpura & ... Sx include: fever ... cutaneous eruptions, diarrhea ... diagnosis #management #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Coronary arteries - Fever ... Vasculitis: • Fevers ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... Vasculitis: • Fevers ... ischemia • Skin: Erythematous ... tract, and often causes ... Differential #Diagnosis #Rheumatology
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