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diagnosis differential causes hematology systemic allergy generalized immunology pruritus common cvid eosinophils hes hypereosinophilia hypereosinophilic hypogammaglobulinemia immunodeficiency naildisorders oncology pathergy
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
Diagnosis Algorithm ... Leukemia • MPN ... Secondary Eosinophilia ... , Sarcoidosis, SLE ... insufficiency, Chronic
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
• Secondary ... and Treatment Algorithm ... #HES #Hematology ... #eosinophilia # ... #management #algorithm
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... • (Peripheral eosinophilia ... develop leukostasis syndrome ... • Tumor lysis syndrome ... bone marrow and secondary
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Creatinine & BUN: • Chronic ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... Pruritus #primary #secondary ... #generalized #dermatology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Abnormality • SLE ... discoloration) • Chronic ... • Nephrotic syndrome ... #dermatology #Differential ... #Diagnosis #Algorithm
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Creatinine & BUN: • Chronic ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... #Pruritus #secondary ... #generalized #dermatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... Autoimmunity • Chronic ... • Infectious diarrhea ... : • Nephrotic syndrome ... Malignancies • Chronic
Pathergy Summary Overview What is pathergy? Pathergy is an exaggerated skin injury occurring after minor trauma such as
• Chronic myeloid ... leukemia (CML) ... interferon-alpha • Atypical eosinophilic ... positive if you see ... allergy #immunology #dermatology
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