12 results
diagnosis hepatology algorithm lfts treatment biliary causes cirrhosis elevated liver pbc primary transaminitis workup aflp aih amyotrophic autoimmune calcium chemistry
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
involving both UMN ... combination of UMN ... involvement • UMN ... conditions listed in differential ... neurology #diagnosis #management
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... >15X ULN ... < 5x ULN ... LFTs #Elevated #Abnormal
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... > 15x ULN • Viral ... 5-15x ULN • Viral ... disease US — Normal ... #LiverEnzymes #Differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
/ULN ALT) / (Alk ... phos/ULN ALP) ... - If both are normal ... • Near normal ... chemistry #diagnosis #differential
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
likely - Mid range/ULN ... Vit D • If all ... normal, move on ... Hypercalcemia #workup #differential ... #diagnosis #endocrinology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
upper limit of normal ... Hepatitis (eg Viral) Management ... + AST > 10x ULN ... 5x ULN AND IgG ... AIH #Diagnosis #Management
Hypocalcemia - Diagnosis and Management PTH Independent (↑ PTH) • LOW VIT D -
Diagnosis and Management ... (phenytoin) • NORMAL ... - Autoimmune: APS ... #endocrinology ... #differential #algorithm
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
(>10^6 IU/mL), normal ... (<2000 IU/mL), normal ... (>10^6 IU/mL), normal ... > ULN, with moderate ... #Indications #management
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Findings: • ↑AST/ALT ... (5-10x ULN), ↑Tbili ... infiltration) Differential ... Intrahepatic Cholestasis Management ... obgyn #diagnosis #management
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
& AST normal or ... • Bilirubin - Normal ... on but elevated as ... > 1.5 x ULN • ... bile ducts Differential
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