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diagnosis hepatology algorithm lfts elevated liver management neurology transaminitis workup aflp als amyotrophic atrophy bandemia biliary calcium causes cbc chemistry
Upper Motor Neuron (UMN) lesions are lesions occurring anywhere in the CNS from the brain up
form part of the differential ... However, in UMN ... UMN lesions are ... and a positive Babinski ... @DharSaty #UMN
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... involving both UMN ... sclerosis with pure UMN ... combination of UMN ... conditions listed in differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Severe - ALT >15X ULN ... Moderate - ALT 5-15X ULN ... Mild - ALT < 5x ULN
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... Severe ALT > 15x ULN ... Mild ALT < 5x ULN ... disease US — Normal ... #LiverEnzymes #Differential
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Cord Disorders - Differential ... injury • Gait is abnormal ... dysfunction • Abnormal ... : Areflexia UMN ... plantar response LMN
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
likely - Mid range/ULN ... FeCa <1 %) - Low normal ... • If all normal ... Hypercalcemia #workup #differential
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... AST/ALT (5-10x ULN ... infiltration) Differential ... diagnosis #management #pathophysiology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
significant: > 10% Band ... Band neutrophils ... ) Differential ... #Bandemia #differential ... CBC #hematology #pathophysiology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... - If both are normal ... of ALP • Near normal ... chemistry #diagnosis #differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... • ALT & AST normal ... • Bilirubin - Normal ... • ALP > 1.5 x ULN ... bile ducts Differential
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