12 results
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... involving both UMN ... conditions listed in differential ... diagnosis column Treatment ... neurology #diagnosis #management
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
upper limit of normal ... Hepatitis (eg Viral) Management ... AND IgG > 2x ULN ... regarding need for treatment ... AIH #Diagnosis #Management
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... AST/ALT (5-10x ULN ... infiltration) Differential ... obgyn #diagnosis #management ... #pathophysiology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
(>10^6 IU/mL), normal ... (<2000 IU/mL), normal ... (>10^6 IU/mL), normal ... IU/mL and ALT > ULN ... #Indications #management
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Examination: • UMN ... Hyperreflexia, Clonus, Babinski ... Multiple Sclerosis Treatment ... sclerosis #diagnosis #management ... #neurology #treatment
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - Differential ... Framework and Management ... Labs: • CPK 5X ULN ... Rhabdomyolysis #Differential ... #Diagnosis #Management
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... • ALT & AST normal ... • Bilirubin - Normal ... • ALP > 1.5 x ULN ... bile ducts Differential
Acute Pancreatitis - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Epigastric abdominal pain (90%, characteristically
Diagnosis and Management ... 2) Lipase > 3x ULN ... diagnosis, can be normal ... hemorrhage Management ... #Treatment #Gastroenterology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... initiation • Differential ... 500 mg QD until normal ... APML #diagnosis #management
Primary Biliary Cirrhosis - Management
A. Initiate therapy 
 - Initiate 1st line therapy with UDCA (13-15
Biliary Cirrhosis - Management ... if ALP > 1.5x ULN ... and/or abnormal ... Non-pharmacological management ... #Treatment #hepatology