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diagnosis hepatology algorithm lfts autoimmune disorders transaminitis workup aih atrophy biliary calcium cardiology causes chemistry cholangitis cirrhosis cord endocrinology evaluation
Upper Motor Neuron (UMN) lesions are lesions occurring anywhere in the CNS from the brain up
Motor Neuron (UMN ... form part of the differential ... However, in UMN ... UMN lesions are ... and a positive Babinski
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Severe - ALT >15X ULN ... kwburak #LFTs #Elevated ... #Abnormal #Transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Severe ALT > 15x ULN ... disease US — Normal ... #LiverEnzymes #Differential
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
likely - Mid range/ULN ... FeCa <1 %) - Low normal ... • If all normal ... Hypercalcemia #workup #differential ... endocrinology #calcium #elevated
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Cord Disorders - Differential ... injury • Gait is abnormal ... dysfunction • Abnormal ... : Areflexia UMN ... plantar response LMN
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
IgG typically elevated ... upper limit of normal ... ALT + AST > 10x ULN ... ALT + AST > 5x ULN ... AND IgG > 2x ULN
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... specificity to elevated ... - If both are normal ... chemistry #diagnosis #differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
• ALT & AST normal ... or slightly elevated ... early on but elevated ... • ALP > 1.5 x ULN ... bile ducts Differential
Hypertensive Disorders of Pregnancy Chronic Hypertension: • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg •
liver enzymes (2x ULN ... of hemolysis, elevated ... obstetrics #cardiology #differential
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... symmetric) • CK > 50 ULN ... kinase levels are elevated ... DM • CPK 10X ULN ... #rheumatology #differential
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