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diagnosis hepatology algorithm lfts autoimmune management neurology transaminitis workup aih amyotrophic biliary calcium causes chemistry cholangitis cirrhosis cord disorders endocrinology
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
involving both UMN ... muscles, muscle atrophy ... progressive muscular atrophy ... loss of muscle (atrophy ... conditions listed in differential
Upper Motor Neuron (UMN) lesions are lesions occurring anywhere in the CNS from the brain up
Motor Neuron (UMN ... form part of the differential ... UMN lesions are ... and a positive Babinski ... @DharSaty #UMN
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... >15X ULN ... < 5x ULN ... kwburak #LFTs #Elevated
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... > 15x ULN • Viral ... disease US — Normal ... #LiverEnzymes #Differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
/ULN ALT) / (Alk ... phos/ULN ALP) ... specificity to elevated ... • Near normal ... chemistry #diagnosis #differential
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
IgG typically elevated ... upper limit of normal ... + AST > 10x ULN ... 5x ULN AND IgG ... > 2x ULN - Certain
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
likely - Mid range/ULN ... Vit D • If all ... normal, move on ... Hypercalcemia #workup #differential ... endocrinology #calcium #elevated
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Cord Disorders - Differential ... injury • Gait is abnormal ... : Areflexia UMN ... plantar response LMN ... Loss of muscle (atrophy
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
& AST normal or ... slightly elevated ... early on but elevated ... > 1.5 x ULN • ... bile ducts Differential
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Antisynthetase syndrome (also ... Polymyositis or ALS ... kinase levels are elevated ... #rheumatology #differential
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