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diagnosis oncology rheumatology algorithm antinxp2 causes chronic dermatologic dermatomyositis distribution erythematosus gap globulin gpa granulomatosis hodgkins leukemia lupus lymphocytic lymphoma
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
: • Squamous cell ... cell carcinoma ... fungoides (cutaneous T-cell ... : • Sickle Cell ... ulcerative #skinrash #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Hepatomegaly • Skin ... lymphoproliferative disorders ... • Neutropenia, anemia ... #oncology #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
disease or more commonly ... Maculopapular rash ... reticularis Differential ... syndrome • Giant cell ... Polyangiitis #GPA #dermatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... Most common cytopenia ... blood count with differential ... Syndromes #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... #hematology #oncology ... #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Disease Classification ... permanent alopecia Differential ... Angioimmunoblastic T-cell ... Kidney disease common ... : • Chronic B-cell
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... carcinoma • Clear cell ... adenocarcinoma • Non-small-cell ... #diagnosis #management ... dermatology
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
adherent scale • Basal ... cell carcinoma ... • Squamous cell ... ; pruritis #dermatology ... #rash #differential
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Solitary Cell Plasmacytoma ... • Plasma cell neoplasms ... MM, the plasma cell ... #Solitary #Cell ... #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... gastric tumors • Hematology ... Thalassemia, Sickle cell ... #diagnosis #hematology
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