12 results
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Marrow (Toxic injury ... mutations) • Immune Aplastic ... #Anemia #oncology
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
peripheral-blood smear ... revealed 25% plasma cells ... PlasmaCell #Leukemia #Smear ... #NEJM
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... = funny-shaped cells ... treatment #hematology #oncology
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
peripheral-blood smear ... acanthocytes (or spur cells ... Spur cells acquire ... #NEJM #clinical ... peripheral #blood #smear
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
• Peripheral smear ... : Smudge cells or ... basket cells can ... Pure red cell aplasia ... diagnosis #workup #oncology
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

 • Plasmacytoid Dendritic Cells (pDC) Neoplasms
 • BPDCN
 • BPDCN
Blastic Plasmacytoid ... Plasmacytoid Dendritic Cells ... @ZhuoerXie #Blastic ... Neoplasm #diagnosis #oncology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
caused by blood cells ... Peripheral Smear ... Causes • Anemia • Aplastic ... Peripheral blood smear ... diagnosis #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... Rapidly rising blast cells ... : Granulocytic cells ... • Peripheral smear ... Leukemia #Hematology #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
• Peripheral smear ... lymphocytes, smudge cells ... Lymphocytic #Leukemia #oncology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Related Acute Lung Injury ... due to marrow aplasia ... potassium from lysed cells