Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells in the marrow Mean age at diagnosis: 70 years old, ~10,000 new cases diagnosed annually in US Features: • Presents with cytopenias (usually anemia). • Bone marrow biopsy needed for diagnosis and risk-stratification • Risks: infection, symptomatic cytopenias, transformation to acute leukemia Management • Conservative/supportive care (growth factors) • Hypomethylating agents to improve counts • Allogeneic stem cell transplant is only curative treatment - BWH Medicine Chiefs @BrighamChiefs #Myelodysplastic #Syndrome #MDS #Diagnosis #Management #treatment #hematology #oncology
