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diagnosis hematology leukemia anemia clinical management chronic cll derm lymphocytic mds myelodysplastic syndrome algorithm aplastic arm autoinflammatory blood causes differential
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic ... Myelodysplastic ... Peripheral Smear ... Peripheral blood smear ... diagnosis #hematology #oncology
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
peripheral-blood smear ... revealed 25% plasma cells ... PlasmaCell #Leukemia #Smear ... #NEJM
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... = funny-shaped cells ... BrighamChiefs #Myelodysplastic ... treatment #hematology #oncology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
multiple myeloma, myelodysplastic ... multiple myeloma or myelodysplastic ... hematopoietic stem cells ... blood myeloid cells ... NEJM Review: https
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
peripheral-blood smear ... acanthocytes (or spur cells ... Spur cells acquire ... #NEJM #clinical ... peripheral #blood #smear
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Normal Blood Smear ... Dysplastic • Myelodysplastic ... Macrocytosis, Target Cells
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... • Hypocellular myelodysplastic ... number of CD34+ cells ... number of CD34+ cells ... Aplastic #Anemia #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... Rapidly rising blast cells ... : Granulocytic cells ... • Peripheral smear ... Leukemia #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Skin: - CLL cells ... • Peripheral smear ... : Smudge cells or ... basket cells can ... diagnosis #workup #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
• Peripheral smear ... lymphocytes, smudge cells ... Lymphocytic #Leukemia #oncology
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