10 results
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Vaughan Williams Classification ... 2 - Beta Blockers ... 3 - Potassium Channel ... alpha & beta adrenergic ... #Classes #pathophysiology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Algorithm Before ... treated with IV potassium ... wasting from other causes ... suggests extra-renal causes ... : • High Blood
Causes of Hyperkalemia - Reduced Excretion - Differential Diagnosis Algorithm

Reduced flow through distal nephron - TTKG
Causes of Hyperkalemia ... • ENaC blockers ... nephropathy • Beta ... #Hyperkalemia #IntercellularShift ... #Causes
The Diagnostic Approach to Hyperkalemia
Drugs
 - Amiloride
 - Spironolactone
 - Triamterene
 - Trimethoprim
 - Pentamidine
 -
inhibitors Other causes ... transplant - SLE High ... - NSAlDs - Beta-Blockers ... #Hyperkalemia #Algorithm ... #differential #causes
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
phlebotomy High ... • Recent IV potassium ... • Beta blockers ... differential #diagnosis #causes ... #potassium #high
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Vaughan Williams Classification ... 2 - Beta Blockers ... 3 - Potassium Channel ... alpha & beta adrenergic ... #Classes #pathophysiology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
phlebotomy High ... • Recent IV potassium ... • Beta blockers ... differential #diagnosis #causes ... #potassium #high
Causes of Hyperkalemia - Differential Diagnosis Framework
 • Cellular Shift:
   - Exercise
Causes of Hyperkalemia ... - Medications: beta ... blockers, digitalis ... Differential #Diagnosis #Causes ... #potassium #high
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
Causes of Hyperkalemia ... Beta-Adrenergic ... Differential #Diagnosis #High ... #Potassium #Classification ... #Causes
Pragmatic diagnostic algorithm for hypokalemia. 
***Typical presentations: 
 • Vomiting: urine Na/Cl > 1.6, low urine
Pragmatic diagnostic algorithm ... urine Na/Cl < 0.7, high ... correcting serum potassium ... angiotensin receptor blockers ... continued in most cases