Thyroid storm is a rare and life-threatening condition characterized by an acute exacerbation of thyrotoxicosis (elevated free triiodothyronine or free thyroxine and suppressed thyrotropin) with severe clinical symptoms. It often results in multiorgan failure involving one or more organ systems such as the central nervous, cardiac, hepatic, pulmonary, respiratory, digestive, and gastrointestinal excretory systems. Specific Strategic Steps for Treatment: • Therapy to control increased adrenergic tone: Beta-blocker • Therapy to reduce thyroid hormone synthesis: Thionamide • Therapy to reduce the release of thyroid hormone: Iodine solution • Therapy to block peripheral conversion of T4 to T3: Iodinated radiocontrast agent, glucocorticoid, PTU, propranolol • Therapy to reduce enterohepatic recycling of thyroid hormone: Bile acid sequestrant #Thyroidstorm #thyroid #thyroidcrisis #beta-blocker #glucocorticoid #Thionamide #Iodine #PTU #triiodothyronine #thyroxine #thyrotropin #propylthiouracil #methimazole