23 results
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... Extrahepatic - Biliary ... Choledocholithiasis, Biliary ... - Obstruction: Biliary ... differential #diagnosis #algorithm
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... US - Dilated Bile ... Duct Stone • Biliary ... Differential #Diagnosis #Algorithm
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... ALP - Biliary ... tree or bile flow ... abnormality vs bone Bili
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... disturbance (obstructed liver ... Highest • Bone • Liver ... PSC - Other biliary ... diseases/Bile duct
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... • US - Normal Bile ... • US - Dilated Bile ... - CBD stone, Biliary
Differential Diagnosis of Biliary Duct Dilation #Diagnosis #EM #IM #GI #Biliary #Bile #Duct #Dilatation #Differential #Algorithm
Differential Diagnosis of Biliary ... Dilation #Diagnosis #EM ... #IM #GI #Biliary ... #Bile #Duct #Dilatation ... #Differential #Algorithm
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... cholestasis → Cirrhosis/Liver ... No extrahepatic biliary ... or higher • Liver ... malignancy #Primary #Biliary
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute Liver ... Hepatocellular - Liver ... hepatitis, Acute biliary ... Extrahepatic • Biliary ... Causes #Acute #algorithm
Biliary Circulation
1) Bile produced in the liver
2) Bile stored in the gallbladder
3) Bile excreted into the
Biliary Circulation ... 1) Bile produced ... in the liver 2) ... returned to the liver ... #Biliary #Circulation
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Stepwise Diagnosis Algorithm ... Benign/malignant biliary ... obstruction, Primary biliary ... Injury #Diagnosis #Algorithm