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Hepatitis B Virus Serology and Interpretation HBsAg - Anti-HBs - Anti-HBc - HBeAg - Anti-HBe - Acute
Hepatitis B Virus ... B - Chronic hepatitis ... (about 10% of cases ... ) - Acute hepatitis ... diagnosis #laboratory #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... Injury - Ichemic hepatitis ... - Autoimmune hepatitis ... Severe #Acute #Causes ... #Differential #Hepatology
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
• Increased bilirubin ... ) • Impaired bilirubin ... hepatocyte damage (eg, hepatitis ... miscellaneous causes ... #differential #causes
Biochemistry and Metabolism of Bilirubin Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
Metabolism of Bilirubin ... → Unconjugated Bilirubin ... "indirect bilirubin ... interchangeably for routine clinical ... pathophysiology #hepatology
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Algorithm and Causes ... Increased Serum bilirubin ... #Differential #Causes ... #Workup #Hematology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Infectious • Hepatitis ... • Alcoholic Hepatitis ... • Drug Induced Hepatitis ... Diagnosis #Algorithm #Causes ... #Hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
>10 mmHg - clinically ... function: INR, bilirubin ... Post-Hepatic: • Cardiac causes ... Cirrhosis/acute hepatitis ... #hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
weeks • Typical clinical ... fold elevation, Bilirubin ... fold elevation, Bilirubin ... Disease #Pregnancy #hepatology ... #obstetrics #hepatitis
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Clinical diagnosis ... of Alcoholic Hepatitis ... • Serum total bilirubin ... Possible ischemic hepatitis ... #AH #hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... #Differential #Hepatology ... #Cirrhosis #Causes
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