101 results
diagnosis rheumatology differential hepatology management dermatology causes disease algorithm photo physicalexam liver treatment video eosinophilia vasculitis rash skin skinrash workup
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
predominantly indirect bilirubin ... • Increased bilirubin ... ) • Impaired bilirubin ... Faulty excretion of bilirubin ... hepatocyte damage (eg, hepatitis
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Conjugation == Gilbert Syndrome ... hyperbilirubinemia syndrome ... autosomal recessive syndrome ... as jaundice on clinical ... #hepatology #diagnosis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
weeks • Typical clinical ... fold elevation, Bilirubin ... necrosis HELLP Syndrome ... Disease #Pregnancy #hepatology ... #obstetrics #hepatitis
Biochemistry and Metabolism of Bilirubin Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
Metabolism of Bilirubin ... → Unconjugated Bilirubin ... "indirect bilirubin ... interchangeably for routine clinical ... pathophysiology #hepatology
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
Hypereosinophilic Syndrome ... Hypereosinophilic Syndrome ... • Clinically ... suspect underlying hematologic ... #HES #Hematology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
• Budd-Chiari Syndrome ... Infectious • Hepatitis ... • Alcoholic Hepatitis ... • Drug Induced Hepatitis ... Algorithm #Causes #Hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Vascular: Budd-chiari syndrome ... Sinusoidal obstruction syndrome ... • Autoimmune hepatitis ... Transaminases #hepatitis ... Diagnosis #causes #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... week • Direct bilirubin ... • Gilbert's syndrome ... #differential #Hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Clinical diagnosis ... of Alcoholic Hepatitis ... • Serum total bilirubin ... Possible ischemic hepatitis ... #AH #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
vein: Budd-chiari syndrome ... week • Direct bilirubin ... Chronic viral hepatitis ... • Gilbert's syndrome ... diagnosis #algorithm #hepatology
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