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Jaundice Differential Diagnosis: A short guide

By Dr. Khudhur Mohammed @khudhur_moh

#jaundice #gastroenterology #algorithm #differential #diagnosis #hyperbilirubinemia #bilirubin
Jaundice Differential ... khudhur_moh #jaundice ... gastroenterology #algorithm #differential ... hyperbilirubinemia #bilirubin
Approach to Neonatal Jaundice

Causes of pathologic hyperbilirubinemia can be classified as due to (1) increased bilirubin
Approach to Neonatal Jaundice ... (1) increased bilirubin ... , (2) impaired bilirubin ... Pediatrics #Neonatal #Jaundice ... #Algorithm #Differential
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... • Increased bilirubin ... postoperative jaundice ... neoplasms #Jaundice ... #unconjugated #differential
Abnormally Colored Urine - Differential Diagnosis Framework
Red:
 - Hematuria, Hemoglobinuria, Myoglobinuria
 - Beets, Rhubarb, Blackberries, Artificial
Colored Urine - Differential ... Dehydration, Increased bilirubin ... Chronic obstructive jaundice ... Discoloration #Differential
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Pruritus, Mild jaundice ... fold elevation, Bilirubin ... fold elevation, Bilirubin ... but variable ++, Bilirubin ... hepatitis #comparison #differential
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
hyperpigmentation • Jaundice ... slightly elevated • Bilirubin ... bile ducts Differential
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice ... birth with serum bilirubin ... associated with bilirubin
Jaundice - Pathophysiology and Causes

- Amy Chung, MD, MSc @AmyChung 

#Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... @AmyChung #Jaundice ... Pathophysiology #Differential
An Approach to Jaundice - Differential Diagnosis

- Increased Production (Prehepatic)
- Decreased Clearance (Intrahepatic + Posthepatic)

Dr. Eric
An Approach to Jaundice ... - Differential ... DrEricStrong #Jaundice ... #Differential #
Differential Diagnosis of Jaundice, Presentation Pattern #Diagnosis #EM #IM #GI #Jaundice #Pattern #LFTs #Workup #Table #Differential
Differential Diagnosis ... of Jaundice, Presentation ... Diagnosis #EM #IM #GI #Jaundice ... Workup #Table #Differential