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Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
New Potassium-Binding ... Agents - Dr. ... Kayexelate #Comparison #Table ... Pharmacology #Patiromer #HyperKalemia ... #Nephrology #Agents
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat ... 10 g QD (adjust dose ... aspiration #Potassium #Binding ... #pharmacology #table
Phosphate binders - quick reference chart of maximum daily dose. Most patients with CKD will require
maximum daily dose ... require phosphate binding ... agents since they ... are not able to ... restricted due to hypercalcemia
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Reflex Testing - Causes ... Hyporeflexia: • Hypercalcemia ... Deep coma (any cause ... stroke, Delayed finding ... differential #diagnosis #table
Treatment of Stable Narrow-Complex Tachycardia
Regular Rhythm:
 • Attempt vagal maneuvers
 • Give adenosine 6 milligrams IV
Repeat 12-milligram dose ... nodal blocking agents ... Treat underlying cause ... Treat underlying cause ... management #cardiology #algorithm
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
/ IBD Renal Loses ... abnormalities - Hypercalcemia ... - Hypokalemia ... Low #Magnesium #Table ... Classification #Causes
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
use of adequate doses ... antihypertensive agents ... with previously stable ... disorders including hypokalemia ... Hyperthyroidism, Hypercalcemia
Emergent Hyperkalemia Treatment Algorithm
ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Emergent Hyperkalemia ... Treatment Algorithm ... -2 hours Dose ... ~2 hours Dose ... removal of offending agent
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Weakness, cramping, nausea ... only if no clear cause ... Elimination (see Table ... Transient, repeat dose ... Treatments: • K-Binding
Causes of Secondary Hypertension - Differential Diagnosis and Screening Testing
Common causes: 
 • Renal parenchymal disease
Causes of Secondary ... Testing Common causes ... (correction of hypokalemia ... withdrawal of suspected agent ... Screening #Workup #table