146 results
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Causes of Severe ... hepatitis - Acute biliary ... Hemochromatosis - Primary ... biliary cholangitis ... Severe #Acute #Causes
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Intestine - Other causes ... - Drugs - Primary ... biliary Cholangitis ... diseases/Bile duct
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Differential Diagnosis Algorithm ... Malignant • Primary ... Biliary Cirrhosis ... Differential #Diagnosis #Algorithm ... #Causes #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... ducts causes cholestasis ... No extrahepatic biliary ... malignancy #Primary ... #Biliary #Cirrhosis
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Differential Diagnosis Algorithm ... on Ultrasound Biliary ... Gallstones • Biliary ... Cholangiocarcinoma • Primary ... #Causes #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Differential Diagnosis Algorithm ... US - Dilated Bile ... Duct Stone • Biliary ... Differential #Diagnosis #Algorithm ... #Causes
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Primary Biliary ... gradual loss of bile ... inflammation and biliary ... Cholestasis #PBC #Primary ... #Biliary #Cirrhosis
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
genes coding for bile ... cholestasis, and some cases ... miscellaneous causes ... external pressure on bile ... #differential #causes
Pruritus - Primary Skin Lesion - Differential Diagnosis Algorithm
Macules / Papules / Plaques:
 • Xerosis (dry
Pruritus - Primary ... Differential Diagnosis Algorithm ... • Arthropod bites ... #Pruritus #primary ... #causes
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
Causes of Ascites ... Differential Diagnosis Algorithm ... liver failure • Primary ... biliary cholangitis ... • Primary sclerosing