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fungal galactomannan biomarkers microbiology risk stratification antibiotics causes differential evaluation falsepositives febrile fungi fungus hematology immunecompromised immunocompromised infant laboratory lp
Fungal Biomarkers: Comparing Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi •
Beta-D-Glucan and Aspergillus ... Polysaccharide cell wall component ... Spec ~77-96% Aspergillus ... Fungal #Biomarkers #BetaDGlucan ... #diagnosis #comparison
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Beta-D-Glucan and Aspergillus ... Polysaccharide cell wall component ... post-2010 almost never ... Fungal #Biomarkers #BetaDGlucan ... #diagnosis #comparison
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
• Cell wall component ... use: Candida, Aspergillus ... constituent of Aspergillus ... post-2010 almost never ... blood products #BetaDGlucan
“Step by Step” – the new kid on the block – aims to risk stratify this
for each of the components ... of the algorithm ... an infant with fever ... CRP < 20 mg/L #Diagnosis ... Stratification #Fever
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
exceptions are Aspergillus ... polysaccharide component ... microscopy #staining #diagnosis ... fungi #fungus #comparison
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Key Components: ... or family - Ever ... physical exam - Key components ... event, follow ACC algorithm ... stratification #diagnosis
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... - Differential Diagnosis ... Algorithm Structural ... Pneumonia • Aspergillus ... #Algorithm #Causes
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