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diagnosis coagulation differential abnormal intravascular management prolonged pt anemia blood dic extravascular hemolysis product reactions thromboticthrombocytopenicpurpura transfusions treatment ttp workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): - Disseminated ... HUS) • Other: Transfusion ... Extravascular #Causes ... differential #diagnosis #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Transfusion Thresholds ... Causes purpura & ... TRALI): Leading cause ... more likely to cause ... diagnosis #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... incompatible blood transfusion ... Treat primary cause ... INR < 2.3 - APTT ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... Decreased factor ... hemorrhage • Disseminated ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Decreased factor ... K deficiency ( decreased ... Disseminated intravascular ... #differential #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
performed PT, PTT ... Mild-to-moderate decrease ... in most cases; ... Platelet count - Decreased ... Diagnosis #Workup #Hematology
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