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diagnosis rheumatology management sle differential druginduced erythematosus systemic comparison dil glomerulonephritis hypokalemia nephrology potassium progressive rapidly rpgn summary table treatment
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... GN, Lupus Nephritis ... Idiopathic • Normal ... Complement: IgA ... differential #diagnosis #algorithm
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
CRP - Usually normal ... in >90% - Low ... complement - Rare ... 60-80% - Low ... complement - 50
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... - CRP: Usually normal ... 60-80% - Low ... complement - 50 ... management of SLE • Evolution
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Algorithm Before ... ↑ Aldosterone: Malignant ... consumption • Low ... /Normal Blood Pressure ... potassium #nephrology #low
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... complements and ... Infections • Malignancy ... , lymphopenia, low ... rule in SLE Malignancy
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... CRP - Usually normal ... in >90% - Low ... complement - Rare ... cutaneous-DIL • Evolution
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