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diagnosis differential rheumatology vasculitis types allergy comparison cryoglobulins dermatology gammopathy glomerulonephritis hypersensitivity mgrs monoclonal petechiae petechial physicalexam progressive rapidly rash
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... immunofluorescence Immune Complex ... staining): • Low Complement ... Lupus Nephritis, Cryoglobulinemia ... differential #diagnosis #algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
deposit of immune complexes ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... diagnosis #types #classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Allergen-specific lgE causes ... Anaphylaxis, Hay fever ... Antigen-antibody complex ... they activate complement ... allergy #table #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tracts Immune Complex ... tract, and often causes ... Vasculitis: • Fevers ... against MPO • Complement ... #rheumatology #classification
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Differential Diagnosis Algorithm ... Red Flags: • Fever ... deficiency Work ... Up: • Complete
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... Diagnostic Workup ... guide subtype classification ... tubulopathy) - Complement ... immunotactoid GN, cryoglobulinemic
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