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rheumatology differential allergy causes cryoglobulinemia cryoglobulins dermatology erythematosus gammopathy hypersensitivity lupus mgrs monoclonal pathophysiology petechiae petechial physicalexam rash reactions renal
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
, seasonal hay fever ... Antigen-antibody complexes ... Complement activation ... #Classification ... Pathophysiology #Allergy #Diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
deposit of immune complexes ... Labs/Diagnosis: ... • Low serum C4 complement ... Cryoglobulins #diagnosis ... #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tracts Immune Complex ... Coronary arteries - Fever ... : • Fevers • ... against MPO • Complement ... #rheumatology #classification
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential Diagnosis ... Algorithm Pinpoint ... Red Flags: • Fever ... deficiency Work ... Up: • Complete
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... anti-Smith Ab, low complements ... Skin Disease Classification ... Differential Diagnosis ... Kikuchi disease • Type-I
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Workup: • Kidney ... guide subtype classification ... tubulopathy) - Complement ... formation causing vasculitis ... Types of MGRS-Associated
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